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      Microscopy of human blood cells and blood vessels

      Lesson details

      Learning outcome

      I can use a light microscope to observe blood cells and blood vessels.

      Key learning points

      1. The parts of a light microscope and their functions, and the sequence of steps for setting up a light microscope.
      2. A light microscope can be used to observe blood cells on a prepared slide.
      3. Observations from a light microscope can be recorded in a labelled scientific line drawing with an indication of scale.
      4. A light microscope can be used to observe sections of blood vessels and differences in the structures of their walls.
      5. Explaining observations from microscopy of differences in the walls of different blood vessels.

      Keywords

      • Light microscope - An instrument that uses visible light and lenses to magnify viewed objects.

      • Lens - Glass or plastic disc that refracts light to increase magnification.

      • Focus - To make an image sharper and clearer.

      • Magnification - The number of times greater in size the viewed object is compared to its actual size.

      • Red blood cell - A cell that transports oxygen around the body.

      Common misconception

      Scientific drawings made using a microscope are difficult to do and often sketched like an artwork. The requirements are clear and precise and require practise to get right.

      The expectations for scientific drawings are clearly stated and shown visually. Opportunities to practise drawing different structures are included throughout the lesson.

      Teacher tip

      Give students plenty of time to make their scientific drawings. Drawing whilst looking down a microscope is really hard to do, so students may be more successful if they draw from a picture displayed on the board or a sheet instead, rather than having to contend with the microscope as well.

      Equipment

      Light microscope, slides of human blood smears and blood vessels.

      Content guidance

      Risk assessment required - equipment

      Supervision

      Adult supervision required

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

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      Prior knowledge starter quiz

      6 Questions

      Q1.
      The photograph shows a piece of apparatus called a light ...

      An image in a quiz
      Correct Answer: microscope

      Q2.
      We are made up of tiny living building blocks called ...

      atoms
      Correct answer: cells
      molecules

      Q3.
      Who is correct?

      Aisha: “Only humans and other animals are made of cells.”
      Lucas: “I think animals and plants are made of cells.”
      Correct answer: Izzy: “All living organisms are made of cells.”

      Q4.
      True or false? Most cells are large enough to see with the unaided eye.

      true
      Correct answer: false

      Q5.
      Match each structure to its function in the human circulatory system.

      Correct Answer:artery,transports blood away from the heart

      transports blood away from the heart

      Correct Answer:blood,liquid that transports cells and dissolved substances

      liquid that transports cells and dissolved substances

      Correct Answer:heart,pumps blood around the body

      pumps blood around the body

      Correct Answer:vein,transports blood back to the heart

      transports blood back to the heart

      Q6.
      Various substances are transported around the human body in the blood. Match each substance to its correct description.

      Correct Answer:carbon dioxide,transported from body cells to the lungs

      transported from body cells to the lungs

      Correct Answer:glucose,transported from the digestive system to body cells

      transported from the digestive system to body cells

      Correct Answer:oxygen,transported from the lungs to body cells

      transported from the lungs to body cells

      Correct Answer:urea,transported from body cells to the excretory system

      transported from body cells to the excretory system

      6 Questions

      Q1.
      Match each part of the microscope to its name.

      An image in a quiz
      Correct Answer:A,eyepiece lens

      eyepiece lens

      Correct Answer:B,objective lenses

      objective lenses

      Correct Answer:C,light source

      light source

      Correct Answer:D,focus wheels

      focus wheels

      Q2.
      Part E is called the ...

      An image in a quiz
      Correct Answer: stage

      Q3.
      On this microscope, the eyepiece lens has a magnification of x10, and the objective lens has a magnification of x40. What is the total magnification?

      An image in a quiz
      x10
      x40
      x50
      Correct answer: x400

      Q4.
      Four students have used a microscope to observe blood cells. Each person has drawn their observations of a red blood cell. Who has produced the best scientific drawing?

      An image in a quiz
      Andeep
      Jacob
      Jun
      Correct answer: Sam

      Q5.
      A student observed a sample of blood using a light microscope. The structure labelled A is …

      An image in a quiz
      a red blood cell.
      a vein.
      Correct answer: a white blood cell.
      an artery.

      Q6.
      These structures observed using a light microscope are an artery and a vein. Which statements explain why structure B is a vein?

      An image in a quiz
      It has a narrow lumen.
      Correct answer: It has a wide lumen.
      It has a thick wall.
      Correct answer: It has a thin wall.

      To help you plan your 10 biology lesson on: Microscopy of human blood cells and blood vessels, download all teaching resources for free and adapt to suit your pupils' needs...