Choose exam board for KS4 Computer Science (GCSE)
Choose exam board for KS4 English
Choose exam board for KS4 French
Choose exam board for KS4 Geography
Choose exam board for KS4 German
Choose exam board for KS4 History
Choose tier for KS4 Maths
Choose exam board for KS4 Music
Choose exam board for KS4 Physical education (GCSE)
Choose exam board for KS4 Religious education (GCSE)
Choose exam board for KS4 Spanish

      Enzymes: function, structure and specificity

      Lesson details

      Learning outcome

      I can explain what an enzyme is and why the shape of an enzyme is important for how it works.

      Key learning points

      1. Enzymes are proteins that act as catalysts, speeding up chemical reactions.
      2. Without enzymes, many reactions would happen too slowly to support life.
      3. Enzymes catalyse reactions essential to life, including digestion and reactions in photosynthesis and respiration.
      4. Each enzyme has a 3D shape with an active site that a specific substrate fits into.
      5. The lock and key model to explain enzyme-substrate interactions.

      Keywords

      • Enzyme - A protein which acts as a biological catalyst.

      • Catalyst - A substance that speeds up the rate of a reaction without being used up.

      • Active site - The part of an enzyme where the substrate binds.

      • Substrate - The substance which is acted upon by the enzyme.

      • Model - Scientists use models as simpler representations of complex things and ideas.

      Common misconception

      That enzymes are used up in reactions, or that an enzyme can catalyse many different reactions.

      Enzymes are not used up in the reactions that they catalyse, and that they can only catalyse one reaction, as explained by the lock and key hypothesis.

      Teacher tip

      If the part on activation energy is too complex, omit it from the lesson. Consider using plasticine modelling instead of drawing the labelled diagram, or having a number of padlocks and keys to try to sort out from each other.

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

      Loading...

      Prior knowledge starter quiz

      6 Questions

      Q1.
      What are the monomers of proteins?

      lipids
      fatty acids and glycerol
      Correct answer: amino acids
      glucose
      starch

      Q2.
      Proteins are used in the body for and repair in the body.

      An image in a quiz
      Correct Answer: growth, growing

      Q3.
      What is a catalyst?

      a substances that slows down chemical reactions
      a substances that stops chemical reactions
      Correct answer: a substances that speeds up chemical reactions

      Q4.
      Scientists use as simpler representations of complex things and ideas.

      An image in a quiz
      Correct Answer: models, model

      Q5.
      Where do consumers in food webs get the nitrogen they need to make proteins?

      air
      water
      soil
      Correct answer: food

      Q6.
      True or false? Photosynthesis and respiration involve a series of chemical reactions.

      Correct answer: True
      False

      6 Questions

      Q1.
      Match each keyword to its meaning.

      Correct Answer:Catalyst,substance which speeds up the rate of a reaction without being used up

      substance which speeds up the rate of a reaction without being used up

      Correct Answer:Substrate,substance which is acted upon by the enzyme

      substance which is acted upon by the enzyme

      Correct Answer:Enzyme,protein which acts as a biological catalyst

      protein which acts as a biological catalyst

      Correct Answer:Active site,part of an enzyme where the substrate binds

      part of an enzyme where the substrate binds

      Q2.
      True or false? All enzymes are proteins.

      Correct answer: True
      False

      Q3.
      Put the following steps in order to describe how an enzyme works.

      1 - The substrate(s) binds to the active site.
      2 - An enzyme-substrate complex is formed.
      3 - The product(s) is released.
      4 - The enzyme can be re-used.

      Q4.
      What part of the enzyme is A?

      An image in a quiz
      Correct Answer: Active site, The active site

      Q5.
      Who is correctly describing the effect of adding an enzyme on the activation energy of an enzyme controlled reaction?

      An image in a quiz
      Andeep: Enzymes increase the activation energy so the reaction happens faster.
      Correct answer: Lucas: Enzymes lower the activation energy so the reaction happnes faster.

      Q6.
      In the lock and key model of enzyme action, what is the lock?

      substrate
      Correct answer: enzyme
      product(s)

      To help you plan your 10 biology lesson on: Enzymes: function, structure and specificity, download all teaching resources for free and adapt to suit your pupils' needs...