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      Diffusion through the cell membrane

      Lesson details

      Learning outcome

      I can explain why some substances can diffuse through the cell membrane and others cannot.

      Key learning points

      1. All substances, including the cell cytoplasm and substances within it, are made up of particles.
      2. Particles of some substances diffuse into and out of a cell by moving through small holes in the cell membrane.
      3. The particles that make up some substances are too big to diffuse through the holes in the cell membrane.
      4. The cell membrane is selectively-permeable because only some substances can diffuse through it.
      5. The net movement of particles through a cell membrane is down a concentration gradient.

      Keywords

      • Cell membrane - All cells are surrounded by a membrane that controls what can enter and leave the cell.

      • Particles - All substances are made up of particles that are too small for us to see.

      • Diffusion - Diffusion is the net movement of particles of a substance down a concentration gradient.

      • Selectively-permeable - A material is selectively-permeable if some substances can move through it but others cannot.

      • Net movement - Net movement is the overall movement of particles from one area to another.

      Common misconception

      Thinking that all, or no, substances can diffuse through the cell membrane. Thinking that cells choose to take in particular substances, or that cells breathe or suck in substances such as oxygen.

      The lesson explores the idea that particles of some, but not all, substances are small enough to diffuse through holes in the selectively-permeable cell membrane.

      Teacher tip

      In Task A, students could be allowed to choose from a collection of objects which one they think is the best model of a cell membrane, or be asked to come up with their own suggestions and then peer assess their objects.

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

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      Prior knowledge starter quiz

      6 Questions

      Q1.
      All animals are made up of tiny living building blocks called .

      Correct Answer: cells

      Q2.
      Which organisms are made up of cells?

      only animals
      only animals and plants
      only animals, plants and fungi
      Correct answer: all organisms

      Q3.
      What is the name of the structure labelled A in the diagram of an animal cell?

      An image in a quiz
      Correct Answer: cell membrane, membrane

      Q4.
      Which diagram best represents the particles that make up the cell cytoplasm?

      diagram A
      Correct answer: diagram B
      diagram C

      Q5.
      The particles of oxygen will move through the cell cytoplasm due to the process of ...

      An image in a quiz
      concentration.
      Correct answer: diffusion.
      gradient.
      solution.

      Q6.
      Which diagram is labelled correctly?

      diagram A: net movement is up a concentration gradient from low to high
      Correct answer: diagram B: net movement is down a concentration gradient from high to low
      diagram C: net movement is against a concentration gradient from low to high
      diagram D: no concentration gradient and no net movement

      6 Questions

      Q1.
      Which of these are features of the cell membrane?

      An image in a quiz
      Correct answer: controls what can enter and leave the cell
      is where cellular respiration takes place
      is where substances are stored
      makes the cell’s food
      Correct answer: surrounds the cell cytoplasm

      Q2.
      Which statement about the cell membrane is true?

      An image in a quiz
      It has no holes in it.
      It has large holes in it.
      Correct answer: It has small holes in it.

      Q3.
      Who has the correct idea about the cell membrane?

      An image in a quiz
      Aisha: “Particles of all substances can move through the holes in the membrane.”
      Alex: “Only large particles can move through the holes in the membrane.”
      Correct answer: Jacob: “Only small particles can move through the holes in the membrane.”
      Sofia: “No particles can move through the holes in the membrane.”

      Q4.
      Which type of particle will not move through the holes in the cell membrane?

      An image in a quiz
      particle A
      particle B
      Correct answer: particle C

      Q5.
      The cell membrane is described as a -permeable membrane.

      Correct Answer: selectively, partially, semi

      Q6.
      Which statement is true?

      An image in a quiz
      Correct answer: Net movement of particles of carbon dioxide will be from the inside to outside.
      Particles of carbon dioxide cannot diffuse through the cell membrane.
      Particles of carbon dioxide will diffuse up the concentration gradient.
      The concentration of particles of carbon dioxide is higher outside the cell.
      There is no concentration gradient across the cell membrane.

      To help you plan your 7 science lesson on: Diffusion through the cell membrane, download all teaching resources for free and adapt to suit your pupils' needs...