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      Adrenaline, thyroxine and negative feedback

      Lesson details

      Learning outcome

      I can describe the roles of the hormones adrenaline and thyroxine in the human body, and explain what is meant by negative feedback.

      Key learning points

      1. The hormone adrenaline is secreted by the adrenal gland during stress; it causes the body to prepare for rapid action.
      2. The hormone thyroxine is secreted by the thyroid gland; it controls growth and the rates of chemical reactions in cells.
      3. The pituitary gland secretes hormones that can control other glands.
      4. The pituitary gland secretes TSH, which causes the thyroid gland to secrete thyroxine.
      5. Thyroxine causes the pituitary gland to stop secreting TSH; this is an example of negative feedback.

      Keywords

      • Adrenaline - A hormone secreted by the adrenal glands in times of fear or stress.

      • Thyroxine - A hormone secreted by the thyroid gland that stimulates the basal metabolic rate.

      • Negative feedback - A mechanism where changes to conditions cause an action to reverse the change, keeping conditions stable.

      • Gland - An organ or tissues that produces and secretes substances, such as hormones.

      Common misconception

      Negative feedback only works to reverse high levels back to normal.

      The slide deck has several slides where changes are described as being high and low and there is a CFU question in the final learning cycle that specifically assesses this misconception.

      Teacher tip

      You can link negative feedback to previous lessons such as regulating blood glucose to reinforce the idea of negative feedback with a different example.

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

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      Prior knowledge starter quiz

      6 Questions

      Q1.
      The image shows glands of the endocrine system. What are the circled glands called?

      An image in a quiz
      thyroid glands
      pancreas
      Correct answer: adrenal glands
      ovaries

      Q2.
      Which hormone is secreted by the adrenal glands?

      thyroxine
      oestrogen
      adrenal stimulating hormone (ASH)
      Correct answer: adrenaline

      Q3.
      Which gland in the human body is involved in regulating metabolism?

      pancreas
      Correct answer: thyroid gland
      testes
      adrenal gland

      Q4.
      What is the name of the hormone secreted by the thyroid gland?

      insulin
      Correct answer: thyroxine
      testosterone
      thyroid stimulating hormone (TSH)

      Q5.
      Which gland is known as the master gland?

      Correct answer: pituitary gland
      hypothalamus
      pancreas
      ovaries
      thyroid gland

      Q6.
      Regulation of constant internal conditions for optimum enzyme activity and cell function is called ...

      Correct Answer: homeostasis

      6 Questions

      Q1.
      Match the hormone to the gland that it is secreted by.

      Correct Answer:adrenaline,adrenal gland

      adrenal gland

      Correct Answer:TSH,pituitary gland

      pituitary gland

      Correct Answer:thyroxine,thyroid gland

      thyroid gland

      Correct Answer:insulin,pancreas

      pancreas

      Q2.
      Which of the following correctly describe the effect of adrenaline on the body?

      Decreased breathing and heart rate.
      Correct answer: Stored glycogen is converted to glucose.
      Correct answer: Blood is diverted to major limb muscles.
      Pupils dilate to become smaller in size.

      Q3.
      What is the mechanism called where the body detects changes in conditions, then reverses these changes to bring levels back to normal?

      Correct Answer: negative feedback

      Q4.
      Put these steps in order to show the body's response to low levels of thyroxine.

      1 - Low thyroxine levels are detected.
      2 - The pituitary gland secretes TSH.
      3 - The thyroid gland is stimulated to produce thyroxine.
      4 - Thyroxine levels increase back to normal.

      Q5.
      Which is true for when thyroxine levels are too high?

      More TSH is secreted by the pituitary gland.
      Correct answer: TSH in inhibited by the thyroid gland.
      Adrenaline is secreted.

      Q6.
      The graph below shows changes in thyroxine over time. Which statements about the graph are correct?

      An image in a quiz
      At point B TSH will have been secreted.
      Correct answer: At point D TSH is being secreted.
      Correct answer: At point B TSH is being inhibited.
      At point D TSH is being inhibited.

      To help you plan your 10 combined science lesson on: Adrenaline, thyroxine and negative feedback, download all teaching resources for free and adapt to suit your pupils' needs...