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      Insulin, glucagon and the control of blood sugar level

      Lesson details

      Learning outcome

      I can describe the role of the hormones insulin and glucagon in controlling blood sugar level.

      Key learning points

      1. If conditions in the body change too much, this can be dangerous to our health.
      2. Glucose travels in the blood and is delivered to cells for respiration.
      3. The hormones insulin and glucagon help to keep human blood sugar level constant.
      4. The pancreas secretes insulin when blood sugar level is too high; the liver absorbs glucose and coverts it to glycogen.
      5. The pancreas secretes glucagon when blood sugar level is too low; the liver converts glycogen into glucose in the blood.

      Keywords

      • Respiration - a chemical reaction in livings organisms that releases energy from glucose

      • Glucose - is a sugar that travels in the blood and is supplied to cells for respiration

      • Glycogen - is a stored form of glucose found in liver and muscle cells

      • Insulin - a hormone secreted by the pancreas when blood glucose is too high, lowering blood glucose levels

      • Glucagon - a hormone secreted by the pancreas when blood glucose is too low, increasing blood glucose levels

      Common misconception

      Not linking the idea that glucose concentration is important for cellular respiration, even during times of rest.

      There are a selection of slides in LC1 that specifically link glucose and respiration and discuss the idea of respiration occurring during rest.

      Teacher tip

      You can role play the sequence of events that occur after the pancreas detects elevated inulin levels. You can model this using diagrams and paper cut outs or your could role play it in person with different stations being the pancreas and liver and students being hormones, glucose and glycogen.

      Equipment

      None required.

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

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      Prior knowledge starter quiz

      6 Questions

      Q1.
      What is the name of the sugar that is a reactant for respiration?

      glycogen
      Correct answer: glucose
      oxygen
      water

      Q2.
      Which gland in the endocrine system is circled in this image?

      An image in a quiz
      adrenal glands
      thyroid gland
      ovaries
      Correct answer: pancreas

      Q3.
      The pancreas is a gland in the endocrine system, what does it secrete?

      lysozyme
      glucose
      Correct answer: hormones
      white blood cells

      Q4.
      Match the activity to the effect it has on blood glucose concentration.

      Correct Answer:eating,increase in blood glucose concentration

      increase in blood glucose concentration

      Correct Answer:exercising,decrease in blood glucose concentration

      decrease in blood glucose concentration

      Q5.
      How do hormones travel around the body?

      in the red blood cells
      along neurones
      Correct answer: in the blood plasma

      Q6.
      In which sub-cellular structure does aerobic respiration take place?

      nucleus
      Correct answer: mitochondria
      ribosome
      chloroplast

      6 Questions

      Q1.
      Which organ in the body detects changes in blood glucose concentration?

      liver
      small intestines
      Correct answer: pancreas
      stomach

      Q2.
      What process regulates the internal conditions in the body for optimum enzyme activity?

      respiration
      digestion
      Correct answer: homeostasis
      body regulation

      Q3.
      Match the hormone to the condition in which they are secreted.

      Correct Answer:insulin,blood glucose too high

      blood glucose too high

      Correct Answer:glucagon,blood glucose too low

      blood glucose too low

      Q4.
      Put these steps in order to show what happens after eating a meal.

      1 - Eating causes an increase in blood glucose concentration.
      2 - The pancreas detects the increase in blood glucose concentration.
      3 - The pancreas secretes insulin into the blood.
      4 - Insulin targets the liver and muscle cells.
      5 - Blood glucose levels decrease back to normal.

      Q5.
      What do liver and muscle cells store glucose as?

      glucagon
      insulin
      starch
      Correct answer: glycogen

      Q6.
      Which statements are true when blood glucose is too low?

      Correct answer: The pancreas secretes glucagon.
      The liver cells absorb more glucose.
      Correct answer: Glycogen in the liver cells is converted into glucose.
      Glucose in blood is stored as glycogen in the liver.

      To help you plan your 10 combined science lesson on: Insulin, glucagon and the control of blood sugar level, download all teaching resources for free and adapt to suit your pupils' needs...