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      Moving into and out of the blood: diffusion, osmosis and active transport

      Lesson details

      Learning outcome

      I can explain how particles of substances move into and out of the blood by diffusion, osmosis and active transport.

      Key learning points

      1. Particles of substances move into and out of the blood through selectively-permeable cell membranes.
      2. Oxygen, carbon dioxide and other small particles move into and out of the blood by diffusion.
      3. Water moves into and out of the blood by osmosis, a type of diffusion.
      4. The net movement of particles by diffusion and osmosis is down a concentration gradient.
      5. Large particles are moved into and out of the blood by active transport, which requires energy.

      Keywords

      • Selectively-permeable membrane - A membrane that will only allow some substances through and not others.

      • Diffusion - Diffusion is the net movement of particles from an area of higher concentration to an area of lower concentration.

      • Net movement - The overall movement of particles.

      • Osmosis - The net movement of water molecules from high to low concentration through a selectively-permeable membrane.

      • Active transport - The net movement of particles against a concentration gradient using energy.

      Common misconception

      Mistakes with the definitions of diffusion, osmosis and active transport are common, as are their application to biological scenarios.

      The definitions are clearly stated and contextualised using key human biological processes and examples.

      Teacher tip

      Use models and simulations to quickly demonstrate the processes of diffusion, osmosis and active transport. Spend time highlighting the important distinctions between each process, and be prepared to thin out the explanations in the lesson to suit the specification and the class.

      Equipment

      None required.

      Licence

      This content is © Oak National Academy Limited (2026), licensed on Open Government Licence version 3.0
      except where otherwise stated. See Oak's terms & conditions
      (Collection 2).

      Lesson video

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      Prior knowledge starter quiz

      6 Questions

      Q1.
      What is the process by which cells release energy?

      Correct Answer: respiration, cellular respiration, aerobic respiration, anaerobic respiration

      Q2.
      What are the reactants needed for cellular respiration?

      Correct answer: oxygen
      carbon dioixde
      water
      Correct answer: glucose

      Q3.
      What gas do red blood cells transport around the body?

      water
      Correct answer: oxygen
      nitrogen

      Q4.
      Which part of the cell controls what enters and leaves the cell?

      An image in a quiz
      cell wall
      Correct answer: cell membrane
      large permanent vacuole
      nucleus
      chloroplast

      Q5.
      Which statement best describes diffusion?

      An image in a quiz
      The net movement of particles from low to high concentration.
      Correct answer: The net movement of particles from high to low concentration.

      Q6.
      Which type of blood vessels has a cell wall that is only once cell thick?

      capillaries
      veins
      arteries

      6 Questions

      Q1.
      Which small particles move into and out of the blood by diffusion?

      lactic acid
      glucose
      Correct answer: urea
      Correct answer: oxygen

      Q2.
      How does water move in and out of the blood?

      Correct Answer: osmosis

      Q3.
      Which particles are moved into and out of the blood by active transport?

      Correct answer: glucose
      Correct answer: lactic acid
      Correct answer: amino acids
      Carbon dioxide
      Water

      Q4.
      True or false? Diffusion occurs down a concentration gradient.

      Correct answer: true
      false

      Q5.
      Which of these processes require energy to take place?

      diffusion
      Correct answer: active transport
      osmosis

      Q6.
      Who best describes net movement?

      Sofia: The number of particles that move from one area to another.
      Sam: The random movement of particles.
      Correct answer: Laura: The overall movement of particles.

      To help you plan your 10 combined science lesson on: Moving into and out of the blood: diffusion, osmosis and active transport, download all teaching resources for free and adapt to suit your pupils' needs...